Adreno Corticotropic Hormone (Acth), Plasma

Adrenocorticotropic Hormone (ACTH), Plasma

What it is

The Adrenocorticotropic Hormone (ACTH) test measures the level of ACTH in plasma. ACTH is a hormone produced by the pituitary gland that stimulates the adrenal glands to release cortisol, a hormone essential for stress response, metabolism, and immune system regulation.

Uses

This test is used to evaluate adrenal gland and pituitary function. It helps diagnose conditions such as Cushing’s syndrome, Addison’s disease, adrenal insufficiency, and pituitary tumors. It is also ordered to investigate abnormal cortisol levels and related hormonal imbalances.

Symptoms That May Lead to the Test

Doctors may order this test if you experience unexplained fatigue, weakness, weight loss or gain, low blood pressure, darkening of the skin, irregular blood sugar levels, or signs of hormonal imbalance. It may also be advised in patients suspected of having adrenal or pituitary disorders.

Abnormal Results

High ACTH: Can indicate Addison’s disease (primary adrenal insufficiency), ectopic ACTH-producing tumors, or Cushing’s disease (pituitary cause of excess cortisol).

Low ACTH: May suggest secondary adrenal insufficiency due to pituitary failure, adrenal tumors, or long-term corticosteroid therapy.

Risks

The ACTH plasma test is a routine blood test and carries minimal risks. Possible side effects include mild pain, bruising, or bleeding at the puncture site. Rarely, dizziness or infection may occur.