ALKALINE PHOSPHATASE, SERUM

Alkaline Phosphatase, Serum

What it is

The Alkaline Phosphatase (ALP) serum test measures the level of alkaline phosphatase enzyme in the blood. ALP is produced mainly in the liver, bones, intestines, and placenta. Elevated or decreased levels can help detect liver disease, bone disorders, or other metabolic conditions.

Uses

This test is commonly used to evaluate liver function, detect bile duct obstruction, diagnose bone diseases such as rickets or Paget’s disease, and monitor treatment of liver or bone disorders. It is often included as part of a liver function panel.

Symptoms That May Lead to the Test

Doctors may recommend an ALP test if you experience symptoms like jaundice, fatigue, abdominal pain, bone pain, frequent fractures, or unexplained weight loss. It is also ordered in patients with suspected liver or bone disease.

Abnormal Results

High ALP Levels: May indicate liver disease (hepatitis, cirrhosis, bile duct blockage), bone disorders (rickets, osteomalacia, bone tumors), hyperparathyroidism, or pregnancy (placental ALP).

Low ALP Levels: May be seen in malnutrition, zinc or magnesium deficiency, hypothyroidism, or rare genetic disorders affecting bone growth.

Risks

The test involves a routine blood draw and carries minimal risks. Possible side effects include mild pain, bruising, or bleeding at the puncture site, and rarely dizziness or infection.