ANTI SACCHAROMYCES CEREVISIAE (ASCA), IGG ANTIBODY

Anti-Saccharomyces Cerevisiae (ASCA), IgG Antibody

What it is

The Anti-Saccharomyces Cerevisiae (ASCA), IgG Antibody test detects IgG antibodies against Saccharomyces cerevisiae, a type of yeast. The presence of ASCA antibodies is strongly associated with Crohn’s disease and helps in differentiating it from ulcerative colitis and other inflammatory bowel diseases (IBD).

Uses

This test is primarily used to support the diagnosis of Crohn’s disease. It may also help distinguish Crohn’s disease from ulcerative colitis when clinical symptoms overlap. Additionally, it can be used along with other serological and imaging tests to evaluate patients with suspected inflammatory bowel disease.

Symptoms That May Lead to the Test

Doctors may recommend this test if a patient has symptoms suggestive of inflammatory bowel disease, such as chronic diarrhea, abdominal pain, unexplained weight loss, blood or mucus in stool, fatigue, and nutritional deficiencies.

Abnormal Results

Positive ASCA IgG: Strongly suggests Crohn’s disease, especially when combined with clinical findings and other diagnostic tests. It may also be positive in a small number of patients with other autoimmune or gastrointestinal conditions.

Negative ASCA IgG: Reduces the likelihood of Crohn’s disease but does not completely rule it out, since some Crohn’s patients may test negative for ASCA antibodies.

Risks

The ASCA IgG test is a standard blood test with minimal risks. Possible side effects include mild pain, bruising, or bleeding at the puncture site, and rarely dizziness or infection.