CERULOPLASMIN, SERUM

Ceruloplasmin, Serum

What it is

The Ceruloplasmin, Serum test measures the level of ceruloplasmin, a copper-carrying protein made in the liver. Ceruloplasmin plays an important role in transporting copper throughout the body and has antioxidant properties. Abnormal levels can indicate disorders related to copper metabolism, liver disease, or certain genetic conditions.

Uses

This test is most commonly used in the evaluation of Wilson’s disease, a rare inherited condition in which copper accumulates in the liver, brain, and other organs. It is also used in the assessment of copper deficiency, Menkes disease, and various liver conditions. Ceruloplasmin testing is often ordered alongside serum copper and 24-hour urinary copper tests for a complete picture of copper balance.

Symptoms That May Lead to the Test

Doctors may recommend this test if you present with unexplained liver disease, neurological symptoms (such as tremors, difficulty speaking, or abnormal movements), psychiatric changes, anemia, or signs of copper deficiency (such as brittle hair and growth delays). It is also ordered in patients with a family history of Wilson’s disease or other metabolic disorders.

Abnormal Results

Low Ceruloplasmin: Strongly associated with Wilson’s disease. May also be seen in Menkes disease, copper deficiency, severe liver disease, or malnutrition.

High Ceruloplasmin: Can occur during pregnancy, with oral contraceptive use, in inflammatory conditions, infections, or certain cancers, since ceruloplasmin is an acute-phase reactant.

Risks

The test involves a standard blood draw with minimal risks such as mild bruising, slight pain, or dizziness at the puncture site. These effects are temporary and rarely serious compared to the value of the information obtained.