DHEA-SULPHATE, SERUM

DHEA-Sulphate, Serum

What it is

The DHEA-Sulphate (Dehydroepiandrosterone Sulphate) test measures the level of DHEA-S in the blood, a hormone produced primarily by the adrenal glands. DHEA-S serves as a stable precursor for androgens and estrogens, the male and female sex hormones. Unlike DHEA, DHEA-S remains in the blood at higher concentrations, providing a reliable marker of adrenal gland activity and androgen production.

Uses

This test is used to evaluate adrenal gland function and to diagnose conditions related to excess or deficient androgen production. It is commonly ordered in the workup of hirsutism, infertility, irregular menstrual cycles, polycystic ovary syndrome (PCOS), adrenal tumors, or congenital adrenal hyperplasia. It can also help assess suspected adrenal insufficiency or premature puberty in children.

Symptoms That May Lead to the Test

Doctors may recommend this test if you experience irregular or absent menstrual periods, excessive hair growth (hirsutism), acne, infertility, deepening of the voice, or signs of virilization in women. In men, it may be ordered for suspected androgen excess or estrogen imbalance. In children, it may be indicated for early or delayed puberty.

Abnormal Results

Elevated DHEA-S: May indicate adrenal tumors, congenital adrenal hyperplasia, PCOS, or other conditions leading to excess androgen production.

Low DHEA-S: May suggest adrenal insufficiency, Addison’s disease, hypopituitarism, or age-related hormonal decline. Low levels may contribute to fatigue, low libido, and reduced bone density.

Risks

The test involves a routine blood draw. Risks are minimal and may include mild pain, bruising, or dizziness at the puncture site. These side effects are rare and temporary.