HERPES SIMPLEX VIRUS 1+2 IGG, SERUM

Herpes Simplex Virus 1+2 IgG, Serum

What it is

The Herpes Simplex Virus (HSV) 1+2 IgG test is a blood test that detects IgG antibodies against both HSV-1 and HSV-2. IgG antibodies appear a few weeks after infection and persist for life, indicating past exposure. HSV-1 is commonly linked with oral herpes (cold sores), while HSV-2 is usually associated with genital herpes. However, both viruses can cause infections in oral or genital areas.

Uses

This test is used to:

• Determine whether an individual has been exposed to HSV-1, HSV-2, or both.
• Differentiate past exposure from recent infection (IgM testing is used for acute cases).
• Assist in the diagnosis of recurrent oral or genital lesions.
• Guide counseling for transmission risks, particularly in couples planning pregnancy or where one partner is HSV-positive.

Symptoms That May Lead to the Test

Your doctor may recommend this test if you have a history of recurrent blisters or ulcers around the mouth or genitals, unexplained lesions, or if you are being evaluated for sexually transmitted infections (STIs). It may also be ordered during prenatal screening, especially if there is a history of herpes exposure.

Abnormal Results

Positive HSV-1 IgG: Indicates past exposure to HSV-1. The virus remains dormant but may reactivate periodically, causing cold sores or oral/genital outbreaks.

Positive HSV-2 IgG: Indicates past exposure to HSV-2, most commonly linked to genital herpes. Transmission risks should be managed, especially with sexual partners.

Negative HSV-1 & HSV-2 IgG: Suggests no prior exposure. However, very recent infections may not yet be detectable (window period).

Risks

The test requires a standard blood draw. Risks are minimal and may include slight pain, mild bruising, or temporary dizziness, which typically resolve quickly.