ANTI DNASE B (ANTIDEOXY- RIBONUCLEASE B), SERUM

Anti-DNase B (Antideoxyribonuclease B), Serum

What it is

The Anti-DNase B (ADB) serum test measures antibodies produced against deoxyribonuclease B, an enzyme released by Group A Streptococcus bacteria. These antibodies typically develop after a strep infection, particularly those involving the throat or skin. This test is useful in identifying recent streptococcal infections, especially when cultures are no longer positive.

Uses

This test helps diagnose complications resulting from a recent streptococcal infection, such as rheumatic fever or post-streptococcal glomerulonephritis (PSGN). It is often ordered alongside the antistreptolysin O (ASO) test to provide a more complete picture of streptococcal antibody response.

Symptoms That May Lead to the Test

Doctors may recommend this test if you present with symptoms suggesting post-streptococcal complications, such as joint pain or swelling, chest pain, shortness of breath, rash, blood in urine, facial or limb swelling, or a recent history of sore throat or skin infection followed by systemic symptoms.

Abnormal Results

Elevated Anti-DNase B Levels: Indicate a recent Group A streptococcal infection and may support the diagnosis of rheumatic fever, glomerulonephritis, or other post-strep complications. Persistently high levels may suggest ongoing immune response.

Normal or Low Anti-DNase B Levels: Suggest no recent strep infection or that antibody levels have already declined after recovery. A negative result does not rule out streptococcal disease and must be interpreted with clinical findings and other tests.

Risks

The test requires a simple blood draw, carrying minimal risks such as mild discomfort, bruising, or lightheadedness. No long-term risks are associated with the procedure.