CARDIOLIPIN ANTIBODIES IGM, SERUM

Cardiolipin Antibodies IgM, Serum

What it is

The Cardiolipin Antibodies IgM test detects IgM autoantibodies in the blood directed against cardiolipin, a type of phospholipid. These antibodies are part of the antiphospholipid antibody (APLA) family and are associated with clotting disorders, pregnancy complications, and autoimmune diseases such as Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE).

Uses

This test helps diagnose Antiphospholipid Syndrome (APS), evaluate unexplained blood clots, investigate recurrent miscarriages, and assess stroke or thrombosis risk in young patients. It is often ordered alongside Cardiolipin IgG, IgA, Beta-2 Glycoprotein antibodies, and Lupus Anticoagulant testing.

Symptoms That May Lead to the Test

Doctors may recommend this test if you have experienced deep vein thrombosis (DVT), pulmonary embolism, stroke or transient ischemic attacks (TIA), repeated pregnancy loss, stillbirth, severe preeclampsia, or unexplained clotting problems at a young age.

Abnormal Results

Positive IgM: Suggests the presence of antiphospholipid antibodies and supports a possible diagnosis of APS, especially if confirmed in repeat testing after 12 weeks. It may also be seen in autoimmune diseases such as lupus or in infections.

Negative IgM: Indicates no detectable cardiolipin IgM antibodies. However, it does not rule out APS since other antibodies (IgG or IgA) may still be present.

Risks

The test is a routine blood test with minimal risks. Mild pain, bruising, or bleeding at the puncture site may occur, and in rare cases, dizziness or infection.