FECAL CALPROTECTIN

Fecal Calprotectin

What it is

The Fecal Calprotectin test measures the level of calprotectin, a protein released by white blood cells (neutrophils), in a stool sample. Elevated calprotectin in stool is a marker of intestinal inflammation. This test helps distinguish between inflammatory bowel disease (IBD), such as Crohn’s disease or ulcerative colitis, and non-inflammatory conditions like irritable bowel syndrome (IBS).

Uses

This test is primarily used to detect and monitor intestinal inflammation. It helps:

• Differentiate IBD (Crohn’s disease, ulcerative colitis) from IBS.
• Assess the severity of bowel inflammation.
• Monitor disease activity and response to treatment in IBD patients.
• Detect relapse or flare-ups in patients with chronic inflammatory bowel conditions.

Symptoms That May Lead to the Test

Doctors may recommend this test if you experience symptoms such as chronic diarrhea, abdominal pain, rectal bleeding, weight loss, fatigue, or persistent gastrointestinal discomfort. It is especially indicated when distinguishing between functional bowel disorders and inflammatory bowel diseases.

Abnormal Results

High Fecal Calprotectin: Indicates intestinal inflammation, often seen in IBD, infections, colorectal cancer, or gastrointestinal bleeding.

Normal / Low Fecal Calprotectin: Suggests absence of significant intestinal inflammation, often consistent with IBS or other non-inflammatory gastrointestinal conditions.

Risks

The test requires only a stool sample, making it completely non-invasive and safe. The main challenge lies in proper stool collection and handling to ensure accurate results.