HEPATITIS E VIRUS IGG ANTIBODY, SERUM

Hepatitis E Virus IgG Antibody, Serum

What it is

The Hepatitis E Virus (HEV) IgG Antibody test detects IgG antibodies against the hepatitis E virus in a blood sample. The presence of IgG antibodies indicates past exposure or infection with HEV and long-term or possibly lifelong immunity. Unlike IgM antibodies, which indicate a recent or acute infection, IgG suggests recovery or prior exposure.

Uses

This test is used to:

• Confirm past infection with hepatitis E.
• Evaluate immunity status after recovery from hepatitis E infection.
• Differentiate between recent (IgM) and past (IgG) HEV infection.
• Support epidemiological studies in areas where HEV is common.

Symptoms That May Lead to the Test

This test is usually performed to check prior exposure and immunity rather than acute infection. However, it may be ordered in cases of unexplained liver enzyme abnormalities, history of jaundice, or if there is suspicion of previous hepatitis E infection. It is also sometimes used in pregnant women and immunocompromised individuals in endemic regions for better risk assessment.

Abnormal Results

Positive HEV IgG: Indicates past exposure or infection, with immunity against hepatitis E. It does not confirm current active infection.

Negative HEV IgG: Suggests no prior exposure and no immunity to hepatitis E. The person may be susceptible to infection.

For suspected acute hepatitis E, testing for HEV IgM antibodies is more appropriate.

Risks

The test involves a standard blood draw. Risks are minimal and may include mild bruising, slight pain, or temporary dizziness at the puncture site, which usually resolve quickly.