HERPES SIMPLEX VIRUS 1 IGG, SERUM

Herpes Simplex Virus 1 (HSV-1) IgG, Serum

What it is

The Herpes Simplex Virus 1 (HSV-1) IgG test is a blood test that detects IgG antibodies against HSV-1. IgG antibodies typically appear a few weeks after initial infection and remain in the body for life, indicating past or chronic exposure. HSV-1 is commonly associated with oral herpes (cold sores), but it can also cause genital infections.

Uses

This test is used to:

• Determine past exposure to HSV-1 infection.
• Differentiate between HSV-1 and HSV-2 infections when combined with type-specific antibody tests.
• Assist in the diagnosis of recurrent oral or genital lesions caused by HSV-1.
• Guide counseling and risk assessment for transmission, especially in couples planning pregnancy.

Symptoms That May Lead to the Test

Your doctor may order this test if you have a history of cold sores, recurrent blisters around the mouth or genitals, or unexplained ulcers. It may also be recommended in cases of suspected herpes exposure, during pre-pregnancy evaluation, or if you are immunocompromised and at risk of complications from HSV infection.

Abnormal Results

Positive HSV-1 IgG: Indicates past exposure to HSV-1. A positive result does not mean you currently have an active infection, but the virus remains latent and can reactivate.

Negative HSV-1 IgG: Suggests no previous exposure to HSV-1. However, if infection was very recent, antibodies may not yet be detectable (“window period”).

Risks

The test involves a standard blood draw. Risks are minimal and include slight pain, bruising, or mild dizziness at the puncture site, which usually resolve quickly.