HERPES SIMPLEX VIRUS 1+2 IGM, SERUM

Herpes Simplex Virus 1+2 IgM, Serum

What it is

The Herpes Simplex Virus (HSV) 1+2 IgM test is a blood test that detects IgM antibodies against HSV-1 and HSV-2. IgM antibodies typically appear soon after an initial infection or during viral reactivation, making this test useful for identifying recent or acute herpes infection. HSV-1 is often linked with oral herpes (cold sores), while HSV-2 is most commonly associated with genital herpes, though either virus can affect both regions.

Uses

This test is used to:

• Detect recent or acute HSV-1 or HSV-2 infection.
• Support diagnosis in patients with new oral or genital blisters or ulcers.
• Differentiate recent infection (IgM) from past exposure (IgG).
• Assist clinicians in evaluating herpes infection in pregnancy, immunocompromised patients, or suspected first-time infections.

Symptoms That May Lead to the Test

Your doctor may recommend this test if you experience symptoms such as painful blisters around the mouth or genitals, burning or tingling sensations before lesion development, swollen lymph nodes, fever, or recurrent painful ulcers. It may also be ordered after potential exposure to HSV through intimate contact.

Abnormal Results

Positive HSV-1/2 IgM: Indicates recent or acute herpes infection, or possible viral reactivation. Confirmatory testing with HSV PCR or culture may be advised due to the possibility of false positives.

Negative HSV-1/2 IgM: Suggests no evidence of recent HSV infection. If symptoms persist, HSV IgG or PCR testing may help rule out a latent or established infection.

Risks

The test involves a routine blood draw. Risks are minimal, including mild bruising, slight pain, or dizziness, which usually resolve quickly.