HERPES SIMPLEX VIRUS 2 IGG, SERUM

Herpes Simplex Virus 2 (HSV-2) IgG, Serum

What it is

The Herpes Simplex Virus 2 (HSV-2) IgG test is a blood test that detects type-specific IgG antibodies against HSV-2. These antibodies typically develop within a few weeks after infection and remain detectable for life, indicating past or established HSV-2 infection. HSV-2 is most commonly associated with genital herpes, though it can also occasionally cause oral lesions.

Uses

This test is used to:

• Identify past exposure to HSV-2 infection.
• Differentiate between HSV-1 and HSV-2 when combined with HSV-1 IgG testing.
• Support diagnosis of genital herpes in patients with recurrent lesions.
• Guide counseling for transmission risk, particularly for sexually active individuals or couples planning pregnancy.

Symptoms That May Lead to the Test

Your doctor may order this test if you have recurrent painful blisters or ulcers in the genital area, tingling or burning sensations before lesion outbreaks, unexplained genital irritation, or if your partner has a known HSV infection. It may also be recommended during STI screenings or prenatal evaluations.

Abnormal Results

Positive HSV-2 IgG: Indicates prior exposure to HSV-2. While this does not necessarily mean an active outbreak, the virus remains latent and may reactivate, causing recurrent genital herpes. Positive individuals may transmit the virus even when asymptomatic.

Negative HSV-2 IgG: Suggests no prior exposure to HSV-2. However, very recent infections may not yet be detectable, so repeat testing may be advised if exposure was recent.

Risks

The test involves a simple blood draw. Risks are minimal and may include slight pain, bruising, or temporary dizziness at the puncture site, which usually resolve quickly.